| FAVOURITE | OPPOSITION | TIME | WIN % | ODDS | PREDICTION |
|---|---|---|---|---|---|
| New York City II | Philadelphia Union II | 23:00 | 29% | 2.30 | HOME DC |
| Floresta EC U20 | Quixada U20 | 18:00 | 51% | 1.44 | HOME WIN |
| Hearts | Aberdeen | 16:30 | 34% | 2.25 | AWAY DNB |
| Deportivo Mixco | Suchitepequez | 21:00 | 52% | 1.53 | HOME WIN |
| Sport Huancayo | FC Cajamarca | 18:00 | 34% | 2.15 | AWAY DC |
| Grau | Sport Boys | 20:30 | 40% | 2.00 | HOME DC |
| Cusco | Cajamarca | 23:00 | 50% | 1.44 | HOME DC |
| Salzburg | Hartberg | 17:30 | 58% | 1.25 | HOME WIN |
| Maldonado | Juventud | 18:00 | 44% | 1.73 | HOME DC |
| Penarol | Cerro Largo | 21:30 | 52% | 1.53 | HOME WIN |