| FAVOURITE | OPPOSITION | TIME | WIN % | ODDS | PREDICTION |
|---|---|---|---|---|---|
| Barracas Central | A. Italiano | 22:00 | 34% | 2.55 | AWAY DNB |
| Montevideo City | Dep. Riestra | 22:00 | 36% | 2.55 | HOME DNB |
| Independiente FBC | Deportivo Santani | 20:00 | 34% | 2.25 | HOME DC |
| Motagua | Genesis | 00:00 | 51% | 1.33 | HOME WIN |
| Real Espana | Marathon | 02:15 | 41% | 1.91 | HOME DC |
| Orlando City | Atlanta Utd | 23:30 | 32% | 2.15 | HOME DC |
| Vermont Green | Boston Bolts | 18:00 | 56% | 1.25 | AWAY WIN |
| Coquimbo | Deportes Tolima | 22:00 | 38% | 2.25 | HOME DNB |
| Fluminense | Bolivar | 22:00 | 66% | 1.17 | HOME WIN |
| Rosario Central | Universidad Central | 22:00 | 66% | 1.17 | HOME WIN |