| FAVOURITE | OPPOSITION | TIME | WIN % | ODDS | PREDICTION |
|---|---|---|---|---|---|
| Olancho | Marathon | 22:00 | 34% | 2.40 | AVOID |
| Jaguares de Cordoba | Barranquilla | 21:00 | 61% | 1.30 | HOME WIN |
| Huila | Orsomarso | 22:00 | 35% | 2.63 | AVOID |
| Real Salt Lake | Minnesota United | 01:30 | 33% | 2.25 | HOME DNB |
| Vancouver Whitecaps | St. Louis City | 01:30 | 50% | 1.36 | HOME DNB |
| Los Angeles Galaxy | Colorado Rapids | 02:30 | 30% | 2.50 | HOME DNB |
| San Diego FC | Portland Timbers | 02:30 | 44% | 1.62 | HOME DNB |
| Atlanta Utd | Toronto FC | 20:00 | 46% | 1.62 | HOME DNB |
| Charlotte | New York Red Bulls | 23:00 | 40% | 1.80 | HOME DNB |
| H. Beer Sheva | Netanya | 17:15 | 51% | 1.36 | AWAY WEH |